![]() ![]() Virchows Arch (2016) 469 (Suppl 1):S1–S346 DOI 10.1007/s0042-7 ABSTRACTS Abstracts XXXI International Congress of the IAP and 28th Congress of the ESP Oral Free Paper Sessions Results: Cytoplasmic MEK1 and DIAPH3 were overexpressed in 74 and 73 CRC cases (49.3 and 48.6 % respectively). Objective: To assess and compare the mutational status of KRAS, NRAS and of Human Pathology, Messina, Italy benefit from MEK1 and DIAPH3 targeted therapies. Barresi ,L.ReggianiBonetti, S.Bettelli,A.Maiorana Patients with non-mucinous carcinomas, and not mucinous ones, can Policlinic G. Unlike mour mass of colon cancer DIAPH3, MEK1 overexpression is associated with better survival. Comparison of KRAS, NRAS and PIK3CA mutational status in Conclusion: MEK1 and DIAPH3 have a significant interrelated role in Poorly Differentiated Clusters (PDC) and corresponding main tu- colorectal carcinogenesis, especially in the non-mucinous type. MEK1 overexpression OFP-01-001 was associated with better overall survival. DIAPH3 overexpression was not significantly associated with any of the tested variables. MEK1 overexpression was significantly associated with OFP-01 Digestive Diseases Pathology - GI positive lymphovascular emboli in the NMA group and with old age in MA group. NMA showed significantly higher MEK1, but not DIAPH3, expression Monday, 26 September 2016, 08.30–12.00, Conference Room 5 than MA. ![]() Oral Free Paper Sessions Oral Free Paper Sessions ![]()
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